Roger E McLendon Selected Research

O(6)-benzylguanine

2/2012	A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: a Pediatric Brain Tumor Consortium study.
10/2009	Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma.
7/2009	Phase 1 trial of temozolomide plus irinotecan plus O6-benzylguanine in adults with recurrent malignant glioma.
3/2009	Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma.
2/2009	Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme.
9/2007	Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma.
10/2005	Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
5/2002	Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.

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Roger E McLendon Research Topics

Disease

98	Neoplasms (Cancer) 01/2021 - 01/2002
58	Glioma (Gliomas) 12/2021 - 01/2002
49	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 11/2002
27	Brain Neoplasms (Brain Tumor) 12/2018 - 01/2002
14	Medulloblastoma 11/2021 - 01/2002
8	Hypoxia (Hypoxemia) 01/2016 - 08/2006
6	Ependymoma 01/2019 - 01/2002
6	Astrocytoma (Pilocytic Astrocytoma) 01/2019 - 01/2002
4	Carcinogenesis 01/2017 - 09/2011
3	Meningioma (Meningiomas) 10/2013 - 01/2012
3	Melanoma (Melanoma, Malignant) 04/2013 - 01/2002
3	Diarrhea 07/2012 - 01/2004
3	Lymphopenia (Lymphocytopenia) 01/2012 - 03/2011
2	Neuroblastoma 01/2021 - 09/2007
2	Poliomyelitis (Polio) 01/2021 - 12/2017
2	Pituitary Neoplasms (Pituitary Adenoma) 01/2020 - 02/2008
2	Intellectual Disability (Idiocy) 01/2017 - 04/2013
2	alpha-Thalassemia 01/2017 - 04/2013
2	Central Nervous System Neoplasms 12/2013 - 09/2012
2	Leukemia 11/2013 - 10/2012
2	Fatigue 07/2012 - 12/2010
2	Hypersensitivity (Allergy) 03/2011 - 11/2010
2	Oligodendroglioma 12/2009 - 01/2006
2	Breast Neoplasms (Breast Cancer) 08/2009 - 11/2003
2	Infections 02/2009 - 02/2008
2	Turcot syndrome 08/2008 - 04/2006

Drug/Important Bio-Agent (IBA)

23	ErbB Receptors (EGF Receptor)IBA 04/2016 - 01/2002
19	Monoclonal AntibodiesIBA 02/2016 - 03/2002
17	Temozolomide (Temodar)FDA LinkGeneric 12/2021 - 02/2003
12	Proteins (Proteins, Gene)FDA Link 01/2019 - 10/2006
12	epidermal growth factor receptor VIIIIBA 01/2018 - 01/2002
10	Bevacizumab (Avastin)FDA Link 01/2014 - 08/2006
9	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2014 - 08/2006
9	Irinotecan (Camptosar)FDA LinkGeneric 01/2014 - 01/2002
8	O(6)-benzylguanineIBA 02/2012 - 05/2002
7	AntigensIBA 01/2018 - 01/2002
6	MethyltransferasesIBA 01/2019 - 10/2005
6	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2019 - 12/2009
6	Biomarkers (Surrogate Marker)IBA 12/2018 - 04/2013
6	Tyrosine Kinase InhibitorsIBA 07/2012 - 11/2002
5	Biological ProductsIBA 01/2021 - 05/2005
5	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 05/2005
5	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2019 - 04/2013
5	VaccinesIBA 01/2018 - 09/2011
5	Peptides (Polypeptides)IBA 01/2013 - 01/2002
4	EnzymesIBA 01/2019 - 02/2006
4	Pharmaceutical PreparationsIBA 01/2018 - 01/2002
4	Immunotoxins (Immunotoxin)IBA 04/2016 - 01/2005
4	Small Interfering RNA (siRNA)IBA 08/2014 - 01/2008
4	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2014 - 11/2005
4	Phosphotransferases (Kinase)IBA 12/2006 - 01/2005
3	Glial Fibrillary Acidic ProteinIBA 01/2019 - 01/2002
3	RNA (Ribonucleic Acid)IBA 01/2017 - 12/2003
3	Carboplatin (JM8)FDA LinkGeneric 09/2016 - 12/2011
3	Neutralizing AntibodiesIBA 01/2013 - 08/2006
3	Erlotinib Hydrochloride (CP 358,774)FDA Link 07/2012 - 01/2010
3	Hydroxyurea (Hydrea)FDA LinkGeneric 01/2012 - 12/2005
3	Imatinib Mesylate (Gleevec)FDA Link 01/2012 - 12/2005
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 04/2011 - 11/2002
3	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 01/2011 - 01/2005
3	TOR Serine-Threonine KinasesIBA 01/2010 - 01/2005
3	O(6)-Methylguanine-DNA MethyltransferaseIBA 12/2009 - 05/2002
3	Gefitinib (Iressa)FDA Link 02/2006 - 11/2002
2	NucleotidesIBA 11/2021 - 01/2021
2	Immune Checkpoint InhibitorsIBA 01/2021 - 02/2016
2	VimentinIBA 01/2019 - 07/2009
2	Mucin-1 (CA 15-3 Antigen)IBA 01/2019 - 07/2009
2	poliovirus receptorIBA 12/2018 - 12/2017
2	Single-Chain AntibodiesIBA 01/2018 - 08/2010
2	Formaldehyde (Formol)FDA Link 12/2017 - 01/2016
2	ParaffinIBA 12/2017 - 01/2016
2	alpha-hydroxyglutarateIBA 01/2017 - 01/2013
2	Messenger RNA (mRNA)IBA 01/2017 - 02/2010
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2017 - 09/2014
2	Histones (Histone)IBA 01/2017 - 10/2012
2	D2C7-(scdsFv)-PE38KDELIBA 04/2016 - 09/2013
2	AntibodiesIBA 02/2016 - 08/2010
2	MicroRNAs (MicroRNA)IBA 01/2016 - 10/2014
2	Membrane Proteins (Integral Membrane Proteins)IBA 09/2014 - 05/2010
2	Transcription Factors (Transcription Factor)IBA 08/2014 - 04/2011
2	Carbonic Anhydrase IXIBA 01/2014 - 01/2008
2	Lysine (L-Lysine)FDA Link 11/2013 - 10/2012
2	SteroidsIBA 10/2013 - 01/2005
2	Alkylating AgentsIBA 08/2013 - 04/2006
2	Angiogenesis InhibitorsIBA 02/2013 - 04/2011
2	Anticonvulsants (Antiepileptic Drugs)IBA 02/2013 - 02/2006
2	GangliosidesIBA 11/2010 - 01/2010
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2010 - 02/2006
2	Immunoglobulin G (IgG)IBA 01/2010 - 06/2006
2	Sirolimus (Rapamycin)FDA Link 01/2010 - 02/2006
2	Trastuzumab (Herceptin)FDA Link 08/2009 - 11/2003
2	Alkyl and Aryl TransferasesIBA 02/2009 - 10/2006

Therapy/Procedure

49	Therapeutics 01/2021 - 01/2002
18	Drug Therapy (Chemotherapy) 01/2021 - 01/2002
15	Radiotherapy 01/2019 - 01/2002
9	Immunotherapy 01/2021 - 10/2009
2	Catheters 12/2018 - 08/2009
2	Chemoradiotherapy 01/2016 - 01/2011
2	Transplantation 01/2016 - 02/2012
2	Craniotomy 08/2013 - 02/2008